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Human Anti-SARS-CoV-2 (2019-nCoV) Spike S (IgM Calibrator) antibody (bs-41407H)
~~~促销,代码KT1102~~~
~~~促销,代码KT1101~~~

~~~20周年感恩回馈“万能卡”~~~
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购传真:010-58129612
技术支持:techsupport@bioss.com.cn
说明书: 下载
1ml/2000.00元
大包装/询价
产品编号 bs-41407H
英文名称 SARS-CoV-2 (2019-nCoV) Spike S (IgM Calibrator)
中文名称 Anti-SARS-CoV-2 Spike S(IgM校准品)
别    名 SARS-CoV-2 spike protein; 2019-nCOV Spike protein; Spike glycoprotein; Spike protein S1; Surface glycoprotein; Spike protein RBD; SPIKE_SARS2; RBD-IgM.  
抗体来源 Human
克隆类型 Polyclonal
产品应用 ELISA=1:100-1000 GICA=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
性    状 Liquid
浓    度 10ug/ml
免 疫 原 Recombinant SARS-CoV-2 Spike Protein: 
亚    型 IgM
纯化方法 Affinity Purification
储 存 液 0.01M PBS(pH7.4) with 0.1% BSA.
保存条件 Store at -20 °C for one years. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

SWISS:
P0DTC2

Gene ID:
43740568

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Anti-SARS-CoV-2 Spike Protein S(IgM校准品)
特性:人源单抗(双链抗体),亲和力高,批次质量稳定
识别位置:新冠病毒S蛋白RBD区域
产品应用:ELISA、胶体金层析、化学发光等
储存条件:-20℃保存,避免反复冻融。
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