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Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (Y453F) protein, His-Tag (bs-41450P)

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说明书: 100ug  500ug  
100ug/3980.00元
500ug/12500.00元
大包装/询价

产品编号 bs-41450P
英文名称 Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (Y453F) protein, His-Tag
中文名称 重组SARS冠状病毒2 Spike突变蛋白RBD (Y453F)
别    名 SARS-CoV-2 spike protein; 2019-nCOV Spike protein; Spike glycoprotein; Spike protein S1; Surface glycoprotein; Spike protein RBD; SPIKE_SARS2; 2019-nCOV Spike RBD (Y453F), Recombinant (His Tag).  
分 子 量 27.8kDa
性    状 Lyophilized or Liquid
种属同源 SARS-CoV-2
序    列 Arg319-Phe541
产品来源 基因工程表达
分    类 重组蛋白
纯化方法 亲和层析
产品应用 Immunology research 
保存条件 Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
产品介绍 The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to specific receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be necessary for the binding of the virus to the host cell at the advent of the infection process. It has been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor-binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 provides essential elements needed for membrane fusion. The S protein plays vital parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; the Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor-binding domain (RBD), leading to a higher mortality rate.

SWISS:
P0DTC2

Gene ID:
43740568

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片
Measured by its binding ability in a functional ELISA. Immobilized human ACE2, His-Avi Tag (Cat: bs-46001P) at 2μg/ml (100ul/Well) can bind SARS-CoV-2 Spike RBD (Y453F), His Tag (Cat: bs-41450P) , the EC50 is 8.34ng/ml.
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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