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Mouse Anti-Cyclophilin B(Loading Control) antibody (bsm-33228M)
~~~促销,代码KT1102~~~
~~~促销,代码KT1101~~~

~~~20周年感恩回馈“万能卡”~~~
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说明书: 50ul  100ul  
50ul/1138.00元
100ul/1880.00元
大包装/询价

产品编号 bsm-33228M
英文名称 Cyclophilin B(Loading Control)
中文名称 亲环蛋白PPIB(内参)单克隆抗体
别    名 Cphn 2; Cphn2; CyP 20b; CYP S1; CYP-S1; CYPB; MGC14109; MGC2224; peptidyl prolyl cis trans isomerase B; Peptidyl prolyl cis trans isomerase B precursor; Peptidyl-prolyl cis-trans isomerase B precursor; Peptidylprolyl isomerase B; PPIase; PPIB; Rotamase; S cyclophilin; SCYLP; PPIB_HUMAN.  
研究领域 肿瘤  细胞生物  免疫学  信号转导  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 4C7
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:500-1000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
细胞定位 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclophilin B: 
亚    型 IgG
纯化方法 affinity purified by Protein G
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 The cyclophilins are a conserved class of proteins that bind the immunosuppressive drug cyclosporin A (CsA) with high affinity. CsA blocks helper T-cell activation at a step between T-cell receptor stimulation and the transcriptional activation of cytokine genes. Cyclophilins from many species possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that is blocked by CsA and therefore may be relevant in CsA-mediated immunosuppression.

Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Subcellular Location:
Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

DISEASE:
Defects in PPIB are the cause of osteogenesis imperfect ype 9 (OI9) [MIM:259440]. OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.

Similarity:
Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
Contains 1 PPIase cyclophilin-type domain.

SWISS:
P23284

Gene ID:
5479

Database links:

Entrez Gene: 5479 Human

Entrez Gene: 19035 Mouse

Entrez Gene: 64367 Rat

Omim: 123841 Human

SwissProt: P23284 Human

SwissProt: P24369 Mouse

SwissProt: P24368 Rat

Unigene: 434937 Human

Unigene: 335249 Mouse

Unigene: 1893 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片
Sample:
Lane 1: Hela (Human) Cell Lysate at 30 ug
Lane 2: A431 (Human) Cell Lysate at 30 ug
Lane 3: HepG2 (Human) Cell Lysate at 30 ug
Lane 4: Thyroid gland (Mouse) Lysate at 40 ug
Lane 5: Thyroid gland (Rat) Lysate at 40 ug
Lane 6: Placenta (Mouse) Lysate at 40 ug
Lane 7: Cerebrum (Mouse) Lysate at 40 ug
Lane 8: Cerebrum (Rat) Lysate at 40 ug
Lane 9: Liver (Mouse) Lysate at 40 ug
Lane 10: Liver (Rat) Lysate at 40 ug
Lane 11: Kidney (Mouse) Lysate at 40 ug
Lane 12: Kidney (Rat) Lysate at 40 ug
Lane 13: Huvec (Human) Cell Lysate at 30 ug
Lane 14: U937 (Human) Cell Lysate at 30 ug
Primary: Anti-Cyclophilin B (bsm-33228M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 20 kD
Observed band size: 20 kD
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