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Mouse Anti-Lamin B (Nuclear Loading Control) antibody (bsm-33040M)
~~~促销,代码KT1101~~~

~~~20周年感恩回馈“万能卡”~~~
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说明书: 50ul  100ul  500ul
50ul/680.00元
100ul/980.00元
500ul/4000.00元
大包装/询价

产品编号 bsm-33040M
英文名称 Lamin B (Nuclear Loading Control)
中文名称 核纤层蛋白B(核内参)单克隆抗体
别    名 lamin B1; LMB1; LMN; LMN2; LMNB 1; LMNB; LMNB1; MGC111419; LMNB1_HUMAN; Lamin-B1.  
产品类型 体育娱乐网址平台 
研究领域 细胞生物  染色质和核信号  信号转导  细胞凋亡  细胞类型标志物  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 9C11
交叉反应 Human,  (predicted: Mouse, Rat, )
产品应用 WB=1:500-1000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
细胞定位 细胞核 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 Recombinant human Lamin B Protein: 
亚    型 IgG1
纯化方法 affinity purified by Protein G
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010].

Function:
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin

Subunit:
Homodimer. Interacts with lamin-associated polypeptides IA, IB and 2.

Subcellular Location:
Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side

Post-translational modifications:
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

DISEASE:
Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P20700

Gene ID:
4001

Database links:

Entrez Gene: 396223 Chicken

Entrez Gene: 4001 Human

Entrez Gene: 16906 Mouse

Entrez Gene: 116685 Rat

Omim: 150340 Human

SwissProt: P14731 Chicken

SwissProt: P20700 Human

SwissProt: P14733 Mouse

SwissProt: P70615 Rat

Unigene: 89497 Human

Unigene: 4105 Mouse

Unigene: 11362 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片
Sample:MOLT-4 Cell (Human) Lysate at 40 ug
Primary: Anti-LaminB(bsm-33040M)at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 64kD
Observed band size: 64kD
Sample:
Molt-4(Human) Cell Lysate at 30 ug
Primary: Anti- Lamin B (bsm-33040M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 64 kD
Observed band size: 67 kD
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