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说明书: 50ul  100ul  200ul
50ul/1138.00元
100ul/1880.00元
200ul/2900.00元
大包装/询价

产品编号 bs-16065R
英文名称 FcRH2
中文名称 CD307b抗体
别    名 CD307b; Fc receptor homolog 2; Fc receptor like protein 2; Fc receptor-like protein 2; FcR-like protein 2; FcRH2; FCRL 2; FcRL2; FCRL2_HUMAN; IFGP family protein 4; IFGP4; Immunoglobulin receptor translocation associated 4 protein; Immunoglobulin receptor translocation-associated protein 4; IRTA4; SH2 domain containing phosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein 1; SPAP1.  
研究领域 细胞生物  免疫学  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FcRH2:51-150/508 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 The Fc receptor homolog (FcRH) family of proteins are related to the classical Fc receptors (FcR) and belong to the immunoglobulin receptor superfamily. The proteins in the FcRH family are type I transmembrane glycoproteins and consist of FcRH1-FcRH6. The genes encoding the human FcRH proteins map to chromosome 1, near the related FCR genes. The FcRH proteins, which are involved in immune system regulation, have immunoreceptor-tyrosine inhibitory motifs in their cytoplasmic domains. Mutations in the gene encoding for the FcRH proteins may be associated with systemic lupus erythematosus, autoimmune thyroid disease and rheumatoid arthritis. The FcRH genes are expressed primarily, although not exclusively, by mature B lineage cells, and may serve important regulatory roles in normal and neoplastic B cell development.

Function:
May have an regulatory role in normal and neoplastic B cell development.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).

Post-translational modifications:
Isoform 2 is N- and O-glycosylated, and phosphorylated.

Similarity:
Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
Q96LA5

Gene ID:
79368

Database links:

Entrez Gene: 79368 Human

Omim: 609251 Human

SwissProt: Q96LA5 Human

Unigene: 437393 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片
Sample:
B16(Mouse) Cell Lysate at 40 ug
Primary: Anti-FcRH2 (bs-16065R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 53 kD
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