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说明书: 50ul  100ul  200ul
50ul/1098.00元
100ul/1880.00元
200ul/2900.00元
大包装/询价
产品编号 bs-11127R
英文名称 CD11b
中文名称 整合素αM抗体
别    名 Antigen CD11b (p170); CD11 antigen like family member B; CD11 antigen like family member C; CD11B; CD11C; Cell surface glycoprotein MAC 1 subunit alpha; CR 3 alpha chain; CR3A; Integrin alpha M; Integrin alpha X; Integrin, alpha M (complement component 3 receptor 3 subunit); Integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Integrin, alpha X (complement component 3 receptor 4 subunit); ITGAM; ITGAX; Leu M5, alpha subunit; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor MO1; Leukocyte adhesion receptor p150,95; Leukocyte surface antigen p150,95, alpha subunit; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Myeloid membrane antigen, alpha subunit; Neutrophil adherence receptor alpha M subunit; p150 95 integrin alpha chain; SLEB6; ITAM_HUMAN; c equivalent; Integrin αM.  
研究领域 神经生物学  细胞粘附分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Horse, )
产品应用 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
细胞定位 细胞浆 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD11b:131-230/1152 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.

Subcellular Location:
Plasma membrane

Tissue Specificity:
Predominantly expressed in monocytes and granulocytes.

DISEASE:
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

SWISS:
P11215

Gene ID:
3684

Database links:

Entrez Gene: 3684 Human

Entrez Gene: 16409 Mouse

Omim: 120980 Human

SwissProt: P11215 Human

SwissProt: P05555 Mouse

Unigene: 172631 Human

Unigene: 262106 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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