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说明书: 50ul  100ul  200ul
50ul/1138.00元
100ul/1880.00元
200ul/2900.00元
大包装/询价

产品编号 bs-2490R
英文名称 CD23
中文名称 CD23/FcεRII抗体
别    名 Fc EpsilonR II; FcεRII; Blast 2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD 23; CD 23A; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon RII; Fc fragment of IgE low affinity II receptor for; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc of IgE, low affinity II, receptor for (CD23); Fc receptor IgE low affinity II alpha polypeptide; Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a; FCE 2; FCE2; FCER 2; FCER2; FCER2A; IgE binding factor; IgE receptor lymphocyte; IgE-binding factor; IGEBF; Immunoglobulin E binding factor; Immunoglobulin E receptor, low affinity II; Low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; Ly-42; Ly42; Lymphocyte antigen CD23; Lymphocyte IgE receptor; MGC93219.  
研究领域 细胞生物  免疫学  干细胞  细胞类型标志物  淋巴细胞  t-淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,  (predicted: Rat, Horse, Rabbit, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
细胞定位 细胞膜 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD23:221-321/321 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a “membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

Function:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Subcellular Location:
Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form.

Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 1 C-type lectin domain.

SWISS:
P06734

Gene ID:
2208

Database links:

Entrez Gene: 2208 Human

Entrez Gene: 14128 Mouse

Omim: 151445 Human

SwissProt: P06734 Human

SwissProt: P20693 Mouse

Unigene: 465778 Human

Unigene: 1233 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD23是一种II型跨膜糖蛋白,是存在于B细胞表面的IgE受体。在慢性B淋巴细胞白血病(CLL)和小B细胞淋巴瘤(SLL)为阳性,套细胞淋巴瘤和小核裂淋巴细胞淋巴瘤阴性。也表达于外周血B细胞的某些亚型、B淋巴细胞和EB病毒转染的B淋巴瘤细胞系。CD23是慢性B淋巴细胞白血病,小B细胞淋巴瘤诊断和鉴别诊断有用的标记物。
产品图片
Sample:
Spleen (Mouse) Lysate at 40 ug
Primary: Anti- CD23 (bs-2490R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 50/40 kD
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