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Rabbit Anti-Nestin/PE Conjugated antibody (bs-0008R-PE)
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购传真:010-58129612
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0008R-PE
英文名称 Anti-Nestin/PE
中文名称 PE标记的巢蛋白/神经上皮干细胞蛋白抗体
别    名 ESTM 46; FLJ 21841; FLJ21841; Intermediate filament protein; Nbla00170; Nes; NEST_RAT; Nestin.   
Journal
PMID
IF
Application
[IF=22.634] Yamamizu, Kohei, et al. "Protein Kinase A Determines Timing of Early Differentiation through Epigenetic Regulation with G9a." Cell stem cell 10.6 (2012): 759-770.  FCM ;  Mouse.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  发育生物学  神经生物学  干细胞  细胞类型标志物  肿瘤细胞生物标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, 
产品应用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 209kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat Nestin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles.
产品介绍 background:
Nestin is a Class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells. This protein has been widely used as a predominant marker for stem / progenitor cells, glioma cells, and tumor endothelial cells in the mammalian CNS. Furthermore, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor.

Function:
Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

Subunit:
Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3.

Subcellular Location:
cytoplasm

Tissue Specificity:
CNS stem cells.

Post-translational modifications:
Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized.

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 10763 Human

Entrez Gene: 18008 Mouse

Entrez Gene: 25491 Rat

Omim: 600915 Human

SwissProt: P48681 Human

SwissProt: Q6P5H2 Mouse

SwissProt: P21263 Rat

Unigene: 527971 Human

Unigene: 331129 Mouse

Unigene: 9701 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


神经干细胞标志物


在动物体早期发育过程中,中枢神经系统发育尤为重要 。Nestin是一种中等纤维蛋白,它在哺乳动物神经前体细胞中表达较高,目前已被广泛用于神经前体细胞的重要标志分子。研究Nestin的表达调控规律,将有助于人们认识神经前体细胞的生物特性。此抗体还表达中枢神经系统干细胞及神经上皮细胞。
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