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Rabbit Anti-FOXA2/PE Conjugated antibody (bs-2358R-PE)
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订购传真:010-58129612
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-2358R-PE
英文名称 Anti-FOXA2/PE
中文名称 PE标记的肝细胞核因子3抗体
别    名 HNF 3beta; Forkhead box A2; Forkhead box protein A2; FOX A2; FOXA2; FOXA2_HUMAN; Hepatic nuclear factor 3 beta; Hepatocyte nuclear factor 3; Hepatocyte nuclear factor 3 beta; Hepatocyte nuclear factor 3-beta; HNF 3B; HNF-3-beta; HNF-3B; HNF3B; MGC19807; TCF 3B; TCF-3B; TCF3B; Transcription factor 3B.  
Journal
PMID
IF
Application
[IF=22.634] Yamamizu, Kohei, et al. "Protein Kinase A Determines Timing of Early Differentiation through Epigenetic Regulation with G9a." Cell stem cell 10.6 (2012): 759-770.  FCM ;  Mouse.  
[IF=6.537] Yamamizu et al. Identification of Transcription Factors for Lineage-Specific ESC Differentiation. (2013) Stem.Cell.Reports. 1:545-59  FACS ;  Human, Mouse, Rat, Chicken, Pig, Cow, Horse.  
[IF=6.2] Yamamizu, Kohei, David Schlessinger, and Minoru SH Ko. "SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1)." Development 141.22 (2014): 4254-4266.  Mouse.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,  (predicted: Rat, Chicken, Pig, Cow, Horse, )
产品应用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HNF 3 beta
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles.
产品介绍 background:
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Function:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Subunit:
Binds DNA as a monomer. Binds TLE1. Interacts with FOXA1 and FOXA3. Interacts with PRKDC.

Subcellular Location:
Nucleus. Cytoplasm.

Post-translational modifications:
Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.

Similarity:
Contains 1 fork-head DNA-binding domain.

Database links:

Entrez Gene: 3170 Human

Entrez Gene: 15376 Mouse

Entrez Gene: 25099 Rat

Omim: 600288 Human

SwissProt: Q9Y261 Human

SwissProt: P35583 Mouse

SwissProt: P32182 Rat

Unigene: 155651 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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