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Rabbit Anti-EP3/PTGER3/AF647 Conjugated antibody (bs-1876R-AF647)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价

产品编号 bs-1876R-AF647
英文名称 Anti-EP3/PTGER3/AF647
中文名称 AF647标记的前列腺素E受体3抗体
别    名 EP 3; EP3; EP3 I; EP3 II; EP3 III; EP3 IV; Ep3 prostanoid receptor; Ep3 receptor; EP3 subtype; EP3e; HGNC:9595; MGC141828; MGC141829; MGC27302; PE2R3_HUMAN; PGE receptor EP3 subtype; PGE2 R; PGE2 receptor EP3 subtype; PGE2-R; PGE2R; Pgerep3; Prostaglandin E receptor 3 (subtype EP3); Prostaglandin E receptor 3; Prostaglandin E receptor EP3 subtype 3 isoform; Prostaglandin E2 receptor; Prostaglandin e2 receptor ep3; Prostaglandin E2 receptor EP3 subtype; Prostaglandin receptor (PGE 2); Prostaglandin receptor 3, EP3, subtype; Prostanoid EP3 receptor; PTGER 3; Ptger3; Ptgerep3; Rep3; rEP3a; rEP3b.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 信号转导  G蛋白偶联受体  新陈代谢  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Pig, Horse, Rabbit, )
产品应用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EP3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Function:
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 5733 Human

Entrez Gene: 19218 Mouse

Entrez Gene: 24929 Rat

Omim: 176806 Human

SwissProt: P43115 Human

SwissProt: P30557 Mouse

SwissProt: P34980 Rat

Unigene: 445000 Human

Unigene: 30424 Mouse

Unigene: 10361 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
Blank control (Black line):Mouse blood (Black).
Primary Antibody (green line): Rabbit Anti-EP3/PTGER3 antibody (bs-1876R-AF647)
Dilution: 3μg /10^6 cells;
Isotype Control Antibody (orange line): Rabbit IgG-AF647 .
Protocol
The cells were fixed with 4% PFA (10min at room temperature)and then were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. Acquisition of 20,000 events was performed.
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